Current Issue : January - March Volume : 2021 Issue Number : 1 Articles : 5 Articles
Pneumonia is the single largest infectious cause of death in children worldwide\nand also a form of an acute respiratory infection that affects the lung.\nThe purpose of the study was to develop a new approach to treat antibiotic-\nresistant K. pneumoniae infection. This study aimed in quest of a drug to\ncombine with ciprofloxacin, a broad spectrum antibiotic frequently used to\ntreat lung infections. Methodology: A total of 23 lung infection bacterial samples\nwere collected and studied against 14 antibiotics of different classes.\nThe disk diffusion method was performed to determine synergy screening,\nMIC value, and qualitative toxicity analysis of ciprofloxacin and chloramphenicol\ncombination. Results: After primary screening of antibiotic susceptibility,\nthey were categorized into multidrug-resistant (MDR), extensively\ndrug-resistant (XDR) and pan drug-resistant (PDR) pathogens where 9 isolates\nwere MDR, 5 were XDR and 3 isolates were PDR. Furthermore, they\nwere trialed in combination ciprofloxacin along with other 7 drugs in disk\ndiffusion to explore the synergistic effect. The combination of ciprofloxacin\nand moxifloxacin, ciprofloxacin and chloramphenicol were found to be synergic.\nThen the MIC test was done for the combination ciprofloxacin and\nchloramphenicol....................................
Effective antimicrobials are crucial for managing Staphylococcus aureus implant-associated\nbone infections (IABIs), particularly for infections due to rifampin-resistant S. aureus (RRSA). Failure\nto remove the implant results in persistent infection; thus, prolonged suppressive antibiotic\ntherapy may be a reasonable alternative. However, a high incidence of adverse events can\nnecessitate the discontinuation of therapy. In this scenario, commercial Staphylococcal bacteriophage\nSb-1 combined with antibiotics is an option, showing a promising synergistic activity to facilitate\nthe treatment of biofilm infections. Therefore, we evaluated the efficacy of the inhibitory activity\nof five antibiotics (doxycycline, levofloxacin, clindamycin, linezolid, and rifampin) alone or\ncombined with phage........................
This study aimed to evaluate the antimicrobial activity of the extract of Libidibia\nferrea L. (228.022-INPA) and a mouthwash formulation against microorganisms\nof the dental biofilm. The extract of Libidibia ferrea L. was prepared\nand formulated with an alcohol-free mouthwash. The Minimum Inhibitory\nConcentrationâ??MIC was determined by microdilution and cell viability\nwas evaluated through fluorescence..............................
Phytol is a diterpene alcohol and can be found as a product of the metabolism of\nchlorophyll in plants. This compound has been explored as a potential antimicrobial agent, but it is\ninsoluble in water. In this study, we describe a novel approach for an interesting anticandidal drug\ndelivery system containing phytol. Different formulations of phytol-loaded solid lipid nanoparticles\n(SLN) were designed and tested using a natural lipid, 1,3-distearyl-2-oleyl-glycerol (TG1). Different\ncompositions were considered to obtain three formulations with 1:10, 1:5, and 1:3 w/w phytol/TG1\nratios. All the formulations were prepared by emulsification solvent evaporation method and had\ntheir physicochemical properties assessed. The biocompatibility assay was performed in the HEK-293\ncell line and the antifungal efficacy was demonstrated in different strains of Candida ssp., including\ndifferent clinical isolates.........................................
Fromtheir discovery, antibiotics have significantly improved clinical treatments of infections,\nthus leading to diminishing morbidity and mortality in critical care patients, as well as surgical,\ntransplant and other types of medical procedures. In contemporary medicine, a significant debate\nregarding the development of multi-drug resistance involves all types of pathogens, especially in\nacute care hospitals due to suboptimal or inappropriate therapy. The possibility of nanotechnology\nusing nanoparticles as matrices to encapsulate a lot of active molecules should increase drug efficacy,\nlimit adverse effects and be an alternative helping to combat antibiotic resistance. The major\naim of this study was to obtain and to analyze physico-chemical features of chitosan used as a\ndrug-delivery system in order to stop the antibiotic resistance of different pathogens. It is well\nknown that World Health Organization stated that multidrug resistance is one of the most important\nhealth threats worldwide. In last few years, nano-medicine emerged as an improved therapy to\ncombat antibiotic-resistant infections agents. This work relies on enhancement of the antimicrobial\nefficiency of ceftriaxone against..........................
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